Nature provides all kinds of natural antihistamine support. This can be fantastic news for people who are looking for natural ways to address Histamine Intolerance. Studies have shown that nature, once again provides those remedies. Let’s take a look at some of the most widely used vitamins, minerals, enzymes and how they might be worth considering when you struggle with histamine intolerance.
Quercetin: When you intake Quercetin, you are helping your body to calm the inflammation. It also blocks the releases of histamine from your mast cells acting like an antihistamine. Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause symptoms related to histamine intolerance. Found in my histamine support pack
DAO™ is a patented enzyme formula containing diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. Found in my histamine support pack
Stinging Nettles Leaf Extract– Stinging nettles leaf is a plant that has been shown to balance immune response, specifically in the airways and nasal passages- it is a natural antihistamine. Studies have shown that the extract of stinging nettles leaf balances a variety of inflammatory activities that affect respiratory health. You can find Stinging nettles leaf in my histamine support pack.
Proteolytic enzymes- Proteolytic enzymes are necessary for breaking down large proteins into smaller ones. Proteolytic enzyme support can help degrade histamine. Proteolytic enzymes also help aid in the absorption of protein, calcium, vitamin B12 and iron- all cofactors needed to make the DAO enzyme. Proteolytic enzymes can reduce circulating allergenic protein complexes. It’s these protein complexes that are associated the allergic reactions seen in histamine intolerance. This is an often overlooked aspect of treating histamine intolerance and it’s one of the reasons I have included the addition of proteolytics in my histamine support pack.
Omega-3 essential fatty acids. Diamine oxidase (the enzyme that breaks down histamine) is continuously released from the intestinal mucosa and carried to the circulation by the lymphatics. Triglycerides and fatty acids like the ones seen in fish oil and other longer chain fatty acids increased diamine oxidase in the intestinal lymph. While this was an observational study, it does bring to light another benefit of taking long chain fatty acids.
Zinc-Concentrations of zinc actually prevent the release of histamine from mast cells, a key component of any natural antihistamine
B6- B6 is another co-factor for producing diamine oxidase production, vitamin B6 like zinc has been shown to be helpful.
Probiotics- There is evidence that B. Longum aids in breaking down histamine and ammonia, as well as increasing levels of butyrate, a short-chain fatty acid responsible for protecting the gut wall. another powerful probiotic is found in the lactobacillus species. L. Plantarum. This good bacteria has frequently been mentioned as one of the best strains of probiotic bacteria for combating histamine issues
Other Vitamin and Minerals That Help Improve DAO Enzyme Activity.
If you take a look at this illustration, you will notice that at the very top we have histamine, histamine is broken down by HNMT on the left and DAO on the right (Blue Circles)
In green letters you are going to see SAMe on the left and Iron, B6, B12, copper and vitamin C on the right. What this means is that if you are deficient in any of these vitamin cofactors, the DAO enzyme or HNMT enzyme won’t work properly, in turn, histamine will not be broken down and ultimately, you will experience excess histamine symptoms. As a Functional medicine practitioner, it becomes important to investigate why a person may have low levels of these vitamins and mineral. So things I want you to consider, if you are woman, and you have a heavy menstrual cycle (hormone imbalances, fibroids, endometriosis,) there is a good change you are iron deficient or iron anemic. Get your iron and ferritin levels checked.
Other considerations are things like hemorrhoids, Ulcers, H.pylori infection, use of proton pump inhibitors, use of birth control pills. These health problems and medications increase likelihood of B12, B6, and vitamin C deficiencies. If you have been pounding down zinc (more than 30-60mg per day) like many patients do when they have leaky gut issues, you might also be low in copper. So again these are all things your Functional Medicine Doctor should start considering.
- Fatigue and Weakness
- Frequent Sickness
- Weak and Brittle Bones
- Problems With Memory and Learning
- Difficulties Walking
- Sensitivity to Cold
- Pale Skin
- Premature Gray Hair
Boosting Your DAO Enzyme Levels- Here’s What You Need To Know…
It would be great if all you needed to do was take some DAO enzyme supplements and call it a day. Unfortunately, it’s a tad more complicated than that. Heres what you need to know. Taking DAO supplements will increase your DAO levels in your digestive tract and enhance histamine breakdown from anything that’s eaten, but it will not stop the histamine that is being produced outside the GI tract.
This is why you need to address the other factors behind Histamine intolerance and MCAS. Taking DAO supplements like HistDAO and Natural D- Hist is a great place to start…. But if you are someone who tried these before and they “didn’t work” keep in mind that there are many things filling up the histamine bucket.
It’s All So Confusing, Where Do I Start?
There are many vitamins and supplements that can help those suffering with histamine intolerance and it can be confusing on knowing where to start. This is why I put together the histamine support pack. You can learn more about why I chose these supplements and decided to offer them in a support protocol. Not only will you save money with the support pack, the histamine support pack was deliberately and carefully designed to address several key areas of histamine intolerance.
People Who Read this Article Also Recommend.
- How To Get Started on a Low Histamine Diet – Part I
- How to Get Started on a Low Histamine Diet-Part II
- Supplements to help support Histamine Intolerances
- Histamine Intolerance and Gut Health
- Estrogen Dominance and Histamine Intolerance- Hormonal imbalances that trigger Histamine/MCAS symptoms
- Why Adrenal Cortisol Testing is so Important for GI Problems
- Natural Ways to Increase DAO enzyme activity to help break down ingested histamine