Gluten, Leaky Gut and Thyroid Disease. Natural Thyroid Support Methods 4

Our unique test from Cyrex Labs (array #3) identifies 15 different components of wheat that can promote inflammation and negatively stimulate the immune system.

 

These reactions and lead to allergies, celiac disease, and other autoimmune diseases.

FAQs

No. This is a cash discount and includes a consultation with Dr Hagmeyer.

This test requires a blood draw. Once the test is purchased, a kit will be sent to you along with instructions and an activation code. Once your test is activated, you will be directed to a local blood draw center to have your blood draw. Specific instructions will be emailed to you regarding fasting or non fasting and if you need to stop any supplements.

Web results are posted within 7-14 business days. Our office will notify you when test results have been reported.

You will be emailed a confirmation from the lab. Within 3-5 business days, you will receive a test kit that you will take to the lab with you. 

Yes. Dr Hagmeyer will review the test result with you. Each test comes with a post-test review/explanation.

One we have placed the order for the test we are unable to issue a refund.

How Do I know If Need this test? Blood tests are commonly used to evaluate a wide range of symptoms and health conditions. Here are some symptoms and situations where someone might seek blood testing:

1. Fatigue or Weakness:
Persistent fatigue or weakness can indicate anemia, thyroid dysfunction, or other underlying conditions.

2. Unexplained Weight Changes:
Sudden weight loss or gain may necessitate blood tests to assess thyroid function, hormone levels, or metabolic conditions.

3. Fever or Infection:
A fever, especially if persistent, may lead to blood tests to identify infections, such as a complete blood count (CBC) to check for signs of infection or inflammation.

4. Joint Pain or Swelling:
Symptoms of arthritis or autoimmune diseases may prompt tests for inflammatory markers or specific autoantibodies.

5. Digestive Issues:
Symptoms like diarrhea, constipation, bloating, or abdominal pain may require tests to assess liver function, pancreatic function, or to check for infections.

6. Skin Changes:
Unexplained rashes, discolorations, or persistent itching may lead to tests for allergies or autoimmune conditions.

7. Mood Changes:
Symptoms of depression, anxiety, or other mood disorders may prompt tests for thyroid function, vitamin D levels, or other hormonal assessments.

8. Menstrual Irregularities:
Irregular or heavy menstrual periods may lead to blood tests to evaluate hormone levels or assess for conditions like polycystic ovary syndrome (PCOS).

9. Chest Pain or Shortness of Breath:
These symptoms may require tests to assess heart function or oxygen levels, including tests for cardiac biomarkers.

10. High Blood Pressure:
Individuals with hypertension may undergo blood tests to assess kidney function, electrolyte balance, and to rule out underlying causes.

11. Chronic Conditions:
Patients with chronic diseases (like diabetes or chronic kidney disease) often have routine blood tests to monitor their condition and manage treatment.

12. Allergies:
Symptoms such as hives or respiratory issues may lead to blood tests for specific allergies.

13. Nutritional Deficiencies:
Symptoms like hair loss, brittle nails, or cognitive changes may prompt testing for vitamin and mineral deficiencies (e.g., vitamin B12, iron, folate).

14. Liver or Kidney Issues:
Symptoms such as jaundice (yellowing of the skin and eyes), dark urine, or swelling in the legs may require liver or kidney function tests.

Order Your Personalized Male & Hormone Test Profile which includes:

  • Comprehensive Male & Hormone Test.
  • One on one consult with Dr. Hagmeyer to discuss Test Results 
  • Recommendations for a Treatment plan and cost of treatment if necessary.

Types of Gluten Intolerance

Gluten intolerance is not as straight-forward as it may seem. Even though useful, traditional blood tests for gluten sensitivities only look at one component of gluten to determine if one is sensitive, alpha gliadin. It is very common for someone who is in fact gluten sensitive to test negative because he or she is does not respond to alpha gliadin.

Gluten and the Brain

This test panel also looks for the potential for gluten to cause addictive behaviors. Specific enzymes in the gut break gluten down into opioids that promote addictive behaviors. One of the major reasons our society has seen a spike in ADD/ADHD, depression, anxiety and other neurological dysfunctions is because of these opioids.

 

The Many Components of Wheat Protein and Why We Test

Wheat/Gluten Sensitivity and Autoimmunity 1

 

Wheat/Gluten Proteome

reactivity & autoimmunity Antigens Tested (IgG and IgA tested separately for each antigen)

  1. Wheat
  2. Wheat Germ Agglutinin
  3. Non-Gluten Proteins-A*
  4. Non-Gluten Proteins-B*
  5. Gliadin Toxic Peptides*
  6. Native + Deamidated Alpha-Gliadin-33-mer
  7. Alpha-Gliadin-17-mer
  8. Gamma-Gliadin-15-mer
  9. Omega-Gliadin-17-mer
  10. Glutenin-21-mer
  11. Gluteomorphin+Prodynorphin
  12. Gliadin-Transglutaminase Complex• Microbial Transglutaminase*
  13. Transglutaminase-2
  14. Transglutaminase-3
  15. Transglutaminase-6

Wheat/Gluten Sensitivity and Autoimmunity 3

 

 

Frequently Asked Questions

Can a person test positive against one of the components of wheat but be negative for a response to the whole kernel of wheat?

Yes. Wheat is made up of many proteins and peptides. The immune response to the whole kernel may be limited, even if a patient is very reactive to the smaller proteins and peptides, such as glutenin or gluteomorphin
 

Are there any medications, foods, conditions, or other factors that could interfere with the results of a Cyrex Labs test?

Yes. While Cyrex Labs is unable to provide an exhaustive answer to this question due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:

a. Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results.
b. Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed.
c. Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex Labs has already developed Array 4 in order to recognize the most common antigens in this regard.
d. A gluten-free diet can cause false negative results on gluten protein/peptide tests.
e. Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.

1-Lian L, Remzi FH, Kiran RP, Fazio VW, Shen B. Clinical implication of false-positive celiac serology in patients with ileal pouch. Dis Colon Rectum. 2010 Oct; 53(10):1446-1451.

 

Why I use Cyrex Labs rather than another lab?

Researchers have proven that 50% of patients diagnosed with Celiac disease do not respond to the one protein being assessed in the conventional tests, instead they react to one or more of the other gluten proteins that are not measured in those conventional tests.  Additionally, more labs are switching to only offering deamidated gliadin because it is more sensitive for Celiac disease.

Unfortunately, the larger percentage of the population, Non-Celiac Gluten Sensitive patients, has been shown to be more reactive to native gliadin.  At Cyrex Labs both native and deamidated gliadin along with other gluten family proteins, the opioid peptides from both gluten and wheat, the lectin portion of wheat and wheat as a whole.

Because not every person’s gluten reactivity manifests as Celiac disease, Cyrex Labs measures antibodies to multiple transglutaminases to capture those patients whose gluten reactivity manifests as skin disorders or neurological complaints.

 

Wheat/Gluten Sensitivity and Autoimmunity 4