Follow on

Free 15 Min Consult
Predictive Antibody Screening- Cyrex Labs-What is it and Who should Get This Test

Cyrex Array 8 Multiple Autoimmune Reactivity Screen

Price: $415

Assists in the early detection of connective tissue disorders, and in monitoring the effectiveness of related treatment protocols. This test evaluates arthritic peptide, collagen complex and fibulin, protein structures that indicate autoimmune reactivity.

Order Now

FAQs

No. This is a cash discount and includes a consultation with Dr Hagmeyer.

Yes. 

This test requires a blood draw. Once the test is purchased, a kit will be sent to you along with instructions and an activation code. Once your test is activated, you will be directed to a local blood draw center to have your blood draw. Specific instructions will be emailed to you regarding fasting or non fasting and if you need to stop any supplements.

Web results are posted within 7-14 business days. Our office will notify you when test results have been reported.

You will be emailed a confirmation from the lab. Within 3-5 business days, you will receive a test kit that you will take to the lab with you. 

Yes. Dr Hagmeyer will review the test result with you. Each test comes with a post-test review/explanation.

One we have placed the order for the test we are unable to issue a refund.

How Do I know If Need this test? Blood tests are commonly used to evaluate a wide range of symptoms and health conditions. Here are some symptoms and situations where someone might seek blood testing:

1. Fatigue or Weakness:
Persistent fatigue or weakness can indicate anemia, thyroid dysfunction, or other underlying conditions.

2. Unexplained Weight Changes:
Sudden weight loss or gain may necessitate blood tests to assess thyroid function, hormone levels, or metabolic conditions.

3. Fever or Infection:
A fever, especially if persistent, may lead to blood tests to identify infections, such as a complete blood count (CBC) to check for signs of infection or inflammation.

4. Joint Pain or Swelling:
Symptoms of arthritis or autoimmune diseases may prompt tests for inflammatory markers or specific autoantibodies.

5. Digestive Issues:
Symptoms like diarrhea, constipation, bloating, or abdominal pain may require tests to assess liver function, pancreatic function, or to check for infections.

6. Skin Changes:
Unexplained rashes, discolorations, or persistent itching may lead to tests for allergies or autoimmune conditions.

7. Mood Changes:
Symptoms of depression, anxiety, or other mood disorders may prompt tests for thyroid function, vitamin D levels, or other hormonal assessments.

8. Menstrual Irregularities:
Irregular or heavy menstrual periods may lead to blood tests to evaluate hormone levels or assess for conditions like polycystic ovary syndrome (PCOS).

9. Chest Pain or Shortness of Breath:
These symptoms may require tests to assess heart function or oxygen levels, including tests for cardiac biomarkers.

10. High Blood Pressure:
Individuals with hypertension may undergo blood tests to assess kidney function, electrolyte balance, and to rule out underlying causes.

11. Chronic Conditions:
Patients with chronic diseases (like diabetes or chronic kidney disease) often have routine blood tests to monitor their condition and manage treatment.

12. Allergies:
Symptoms such as hives or respiratory issues may lead to blood tests for specific allergies.

13. Nutritional Deficiencies:
Symptoms like hair loss, brittle nails, or cognitive changes may prompt testing for vitamin and mineral deficiencies (e.g., vitamin B12, iron, folate).

14. Liver or Kidney Issues:
Symptoms such as jaundice (yellowing of the skin and eyes), dark urine, or swelling in the legs may require liver or kidney function tests.

Order Your Personalized Male & Hormone Test Profile which includes:

  • Comprehensive Male & Hormone Test.
  • One on one consult with Dr. Hagmeyer to discuss Test Results 
  • Recommendations for a Treatment plan and cost of treatment if necessary.

Clinical Use

  • Assist in the early detection of mixed connective tissue disorders
  • Assist in monitoring the effectiveness of related treatment protocols
 

Recommended for Patients Who

  • Have Arthritis or Arthralgias
  • Have joint inflammation following exposure to environmental triggers
 

Antigens Tested (IgG + IgA Combined)

  • Arthritic Peptide
  • Collagen Complex
  • Fibulin
 

Function Arthritic Peptide

Arthritic peptide, glucose-6-phosphate isomerase, is an endogenous molecule associated with joints. This cytoplasmic enzyme catalyzes the second step of glycolysis and is found at low levels in serum. Arthritic peptide can stimulate KRN T cells when processed and presented by antigen presenting cells.

 

Antibodies Appear:

  1. Mixed Connective Tissue Disease 1
  2. Osteoarthritis 2
  3. Rheumatoid Arthritis 1, 2, 3
 

Clinical Significance:

High levels of antibodies to arthritic peptide are found in patients with mixed connective tissue diseases including rheumatoid arthritis.1, 3 Musculoskeletal manifestations of Celiac disease include metabolic bone disease, muscle weakness, osteoarthritis, osteomalacia and polymyalgia rheumatic.2 Due to mucosal immune over-activation in rheumatoid arthritic patients, there is high cross-reactivity between joint tissues and foods, notably gluten, dairy peptides and pork.4 Thus, for better outcome with autoimmune arthritic patients, a tailored diet should be implemented.

 

References:

  1. Basu, et al. Molecular basis for the recognition of an arthritic peptide and a foreign epitope on distinct MHC molecules by a single TCR. J Immunol, 2000; 164:5788-5796.
  2. Bourne, et al. Arthritis and coeliac disease. An Rheum Dis, 1985; 44:592-598.
  3. Francis, et al. The prevalence of coeliac disease in rheumatoid arthritis. Eur J Gastroenterol Hepatol. 2002; 14:1355-1356.
  4. Hvatum, et al. The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis. Gut, 2006; 55:1240-1247.
 

Function Collagen Complex 

Collagen is a group of proteins found in the flesh and connective tissues. The most abundant protein of the human body, Collagen is the main component of connective tissue. Collagen is found in tissues such
as tendon, ligament and skin, and is also abundant in cornea, cartilage, bone, blood vessels, the gut, and intervertebral disc. The fibroblast is the most common cell which creates collagen. In muscle tissue, collagen serves as a major component of the endomysium.

 

Antibodies Appear:

  • Arthritis 4
  • Goodpasture’s Syndrome* 1
  • Type 1 Bullous
  • SLE 3

Clinical Significance:

High levels of antibodies to Collagen Complex are noted in autoimmune arthritic disorders.3, 4 Circulating antibodies to collagen appear years before the clinical onset of arthritic conditions and is therefore considered an early biomarker or predictor of autoimmune arthritis.2

Blistering seen in bullous systemic lupus erythematosus may not always be widespread as shown by Fujii et al,3 they can develop on limited parts of the body. Circulating collagen antibodies demonstrate the involvement of an autoimmune mechanism.3

In a rat study, Arends et al. were able to show that infections with microbial peptides may induce antiglomerular basement membrane disease or Goodpasture’s syndrome through T cell epitope mimicry.*

 

References:

  1. Arends, et al. T cell epitope mimicry in antiglomerular basement membrane disease. J Immunol, 2006; 176:1252-1258.
  2. Dzhambazov, et al. Therapeutic vaccination of active arthritis with a glycosylated collagen type II peptide in complex with MHC class II molecules. J Immunol, 2006; 176:1525-1533.
  3. Fujii, et al. Detection of anti-type VII collagen antibody in Sjögren’s syndrome/lupus erythematosus overlap syndrome with transient bullous systemic lupus erythematosus. Br J Dermatol, 1998; 139:302-306.
  4. Khare, et al. Oral https://drhagmeyer.com/wp-content/uploads/2022/08/pexels-karolina-grabowska-5904094-1.pngistration of immunodominant human collagen peptide modulates collagen-induced arthritis. J Immunol, 1995; 155(7):3653-3659.
  5. Vojdani. A potential link between environmental triggers and autoimmunity. Autoimmune Dis, 2014; 2014:437231.
  6. Lundberg, et al. Periodontitis in RA – the citrullinated enolase connection. Nat Rev Rheumatol, 2010; 6(12):727-30.
  7. Ebringer, et al. Ankylosing spondylitis, HLA-B27 and Klebsiella – an overview: proposal for early diagnosis and treatment. Curr Rheumatol Rev, 2006; 2(1):289-297.
  8. Petković and Metlas. Cross-reactivity of the V3-specific antibodies with the human C1q. Z Naturforsch C, 2001; 56(11- 12):1135-1143.
  9. Werkmeister, et al. Characterisation of a monoclonal antibody against native human type I collagen. Eur J Biochem, 1990; 187:439-443.
  10. Sakaguchi,etal.ReactivityofIgEandIgGantibodiestohumancollagentype1inchildrenwithbovinegelatinallergy.JAllergy Clin Immunol, 2004; 113(2):S181.
 

Fibulin Function:

Fibulin is a calcium-binding glycoprotein found in blood and extracellular matrices. In the extracellular matrix, Fibulin associates with basement membranes and elastic fibers. This association with these matrix structures is mediated by Fibulin’s ability to interact with numerous extracellular matrix constituents including fibronectin, proteoglycans, laminins and tropoelastin. In blood, Fibulin binds to fibrinogen and incorporates into clots.

 

Antibodies Appear:

  • Atherosclerotic Lesions 1
  • Osteoarthritis 3
 

Clinical Significance:

Antibodies to Fibulin may be a contributing factor in the immunological pathways implicated in the pathogenesis of Osteoarthritis.3 To a lesser extent, anti-Fibulin antibodies were found in patients with Reumatoid Arthritis, Systemic Lupus Erythematosus and Systemic Scleroderma.3 Due to its characteristic of fibrinogen-binding,1, 2 Fibulin has been shown to play a role in the etiology and progression of cardiovascular diseases. Fibulin is a coagulation component of coronary artery atherosclerotic lesions.1, 2

 

References:

  1. Argraves, et al. Fibulin-1 and fibrinogen in human atherosclerotic lesions. Histochem Cell Biol, 2009; 132:559-565.
  2. Tran, et al. The interaction of fibulin-1 with fibrinogen: A potential role in hemostasis and thrombosis. J Biologic Chem, 1995; 270(33):19458-19464.
  3. Xiang, et al. Fibulin-4 is a target of autoimmunity predominantly in patients with osteoarthritis. J Immunol, 2006; 176:3196-3204.