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Methyl Detox Profile Plus 30 Minute Consult

$625.00

Description

More than 50% of the population are affected by genetic mutations in the methylation pathway.1 The Methyl Detox profile provides greater insight into genetic variations of the following MTHFR, MTR, MTRR, COMT and AHCY pathways.Standard MTHFR genotyping only evaluates folic acid metabolism. The MethylDetox Profile makes it easy to understand the complicated methylation process by giving comprehensive insights into the functional status of the methylation pathway.

Methylation can play an important role in many chronic diseases. By understanding your genetics you can prevent and address these conditions with the right nutrition.

The MethylDetox Profile tests critical genes in the methylation pathway. By understanding your genes and how they impact methylation, you may prevent and address existing health problems with the right nutrition.

This profile provides greater insight into genetic variations of the following MTHFR, MTR, MTRR, COMT and AHCY pathways.

The MethylDetox Profile includes genetic markers involved in methylation and homocysteine metabolism provided in a detailed lab report with personalized commentary. Additionally, continued homocysteine testing enables easy monitoring of patient progress.
Genetic variations in this pathway are associated with elevated homocysteine levels, impaired methylation processes and limited detoxification capacity. 1, 3

As a result, these SNPs (single nucleotide polymorphisms) may contribute to accelerated aging, certain chronic diseases like cardiovascular disease and neurodegenerative disorders, impaired gene-regulation, poor drug clearance, and impaired neurotransmitter metabolism. 1, 3-21

Comprehensive testing for methylation and detoxification

The MethylDetox Profile gives more actionable information than MTHFR testing alone, giving you a more complete picture of your body’s methylation and detoxification. The MethylDetox profile includes suggestions for specific nutrient needs to address with practitioner guidance.

Standard MTHFR genotyping only evaluates folic acid metabolism. Scientific research reveals that a variety of genes are involved in maintaining methionine/homocysteine balance. Genetic variations (SNPs) in these important genes influence your methylation potential. Individual methylation is monitored using homocysteine levels. Important SNPs are included to evaluate your ability to methylate neurotransmitters, DNA, and toxins.

Who May Benefit from This Test?

Individuals with any of the following diagnoses or symptoms:

  • Cardiovascular Diseases e.g. hypertension, coronary artery disease, stroke 4-10
  • Neurological Disorders e.g. depression, dementia, Alzheimer’s disease, ADD/ADHD, ASD, chronic fatigue syndrome, migraine, insomnia 7, 10-17
  • Metabolic Conditions e.g. metabolic syndrome, diabetes mellitus, kidney diseases, reduced ability to metabolize medications, multiple chemical sensitivity 10, 18-21
  • Musculoskeletal Disorders e.g. osteoporosis 10, 22
  • Eye Diseases e.g. macular degeneration 23, 24
  • Cancer e.g. colorectal, breast, and others 1, 10, 25

Methyl Detox testing and consult

What kind of Patient Is Methyl Detox Profile Order for?

Individuals with a manifestation and/or family history of:

  • Cardiovascular disease
  • Hypertension, coronary artery disease, stroke
  • Neurodegenerative disorders
  • Poor drug clearance
  • Polypharmacy
  • Multiple chemical sensitivity (MCS)
  • Chronic fatigue syndrome (CFS)
  • Chronic metabolic disorders
  • Metabolic syndrome
  • Diabetes
  • Kidney or liver disease
  • Musculoskeletal disorders
  • Autism spectrum disorder
  • Depression/anxiety
  • Insomnia
  • ADD/ADHD
  • Alzheimer’s Disease

What’s Being Tested in the Methyl Detox Profile

  1. MTHFR
  2. MTR
  3. MTRR
  4. COMT
  5. AHCY

Homocysteine can also be done but is the only test requires a blood draw. This is an add on with extra cost.

Understanding Methionine and Homocysteine Balance

The primary purpose of methionine/ homocysteine balance is to ensure proper methylation by donating methyl groups for:

  • DNA methylation (gene regulation)
  • Regulation of neurotransmitters (e.g. epinephrine, norepinephrine, and serotonin)
  • Detoxification of catecholamines from the environment
  • Drug clearance (phase II liver detoxification)
  • Homocysteine is also a precursor in the biosynthesis of L-cysteine for glutathione; glutathione is important for the detoxification of electrophilic compounds (metals).
  • Elevated serum homocysteine is a widely accepted marker for methionine/homocysteine imbalance, which is a genetically controlled process. 28

Elevated homocysteine levels can lead to accelerated aging, cardiovascular disease and neurodegenerative disorders among others. 20, 21, 29

The Methyl Detox Profile includes

  1. MTHFR
  2. MTR
  3. MTRR
  4. COMT
  5. AHCY
  6. 30 minute consult with Dr Hagmeyer.

Methyl Detox Profile testing

Test Components

1. MTHFR

The MTHFR gene’s purpose is to produce the important MTHFR enzyme in the body. This enzyme is an important part of maintaining optimal health. If the MTHFR gene has a variant, folate metabolism can be negatively impacted. Improper folate metabolism is implicated in many different diseases. 5, 6, 10, 26-29

2. MTR

MTR codes for the enzyme, methionine synthase (MS). MS converts homocysteine to methionine using methylated vitamin B12. variants in this gene significantly impact homocysteine metabolism, which can increase the risk for a number of chronic conditions such as cardiovascular diseases, metabolic and neurological conditions and certain cancers. 30

3. MTRR

The MTRR gene codes for the important enzyme, methionine synthase reductase (MSR). Methionine synthase reductase is required for the proper function of methionine synthase (see MTR). Both genes act together to convert homocysteine to methionine. variants can be involved with the development of cancers, Parkinson’s disease, depression, hypertension and many others. 31-36

4. COMT

COMT is the major gene involved in methylation. It plays an important role in a variety of disorders, including estrogen-induced cancers, Parkinson’s disease, depression, hypertension and many others. COMT is also necessary for maintaining the proper balance of neurotransmitters with SAMe obtained from methionine. Genetic variants in COMT can result in various neurological problems and has also been associated with Autism. 31-36

5. AHCY

AHCY is the only enzyme known to convert S-Adenosylhomocysteine (AdoHcy) to homocysteine. It is crucial that AHCY immediately converts AdoHcy to homocysteine and adenine in order to maintain optimal methylation potential. Studies show a link between variants in this gene with poor methylation potential and severe myopathies, developmental delays and hypermethioninemia.

6. Homocysteine

Homocysteine is an amino acid that is involved in maintaining the methionine cycle. Elevated homocysteine levels are well known risk factors for chronic disease, particularly cardiovascular, diabetes and neurodegenerative disorders 7, 10, 37

Testing components of Methy Detox Profile

Literature

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