Supplements to Help with Histamine Intolerance- Histamine Support Pack
Histamine intolerance occurs when there is a buildup of histamine in the body. Drugs, medical conditions, the environment, nutritional deficiencies, and diet can lead to histamine intolerance.
Factors that lead to histamine intolerance cause the following:
- An increase in how much histamine a person’s digestion releases.
- A decrease in the effectiveness or abundance of diamine oxidase, or DAO, the primary enzyme that breaks down ingested histamine.
- A decrease in the effectiveness or abundance of histamine-N-methyltransferase, or HNMT, an enzyme that helps break down histamine within cells.
Common factors that interfere with DAO and HMNT levels include many prescription drugs, for example:
- airway medications, such as theophylline
- heart medications
- muscle relaxants
- pain medications
- gastrointestinal medicines
- nausea and gastroesophageal reflux disease, GERD
- malaria drugs
- tuberculosis medications
The list also includes over-the-counter (OTC) and prescription anti-inflammatories (NSAIDs) and painkillers, such as:
- acetylsalicylic acid (aspirin)
- indomethacin (Indocin)
- diclofenac (Voltaren)
Other influencing factors include:
- intestinal conditions or injuries that compromise the gut lining and affect digestion
- liver conditions
- vitamin B-6, vitamin C, copper, or zinc deficiencies
- extreme or chronic stress
- low oxygen states
- injury or trauma
- temperature extremes