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Neurotransmitter Testing

Neurological Psych Test

Price: $879 (Testing and Consult) Genetic 27 variants

For our Neurological / Psych Nutrigenomic Panel, 27 gene variants have been chosen by our experts to be analyzed for SNPs (single nucleotide polymorphisms).

FAQs

No- This test is done at home and comes with prepaid shipping materials and everything you need to ensure proper delivery to the lab.

Web results are posted within 7-14 business days. Our office will notify you when test results have been reported.

Yes. The kit comes with easy to follow instructions

 

Yes. Dr Hagmeyer will review the test result with you. Each test comes with a 30-45 minute post-test review/explanation.

 

One we have placed the order for the test we are unable to issue a refund.

 

Who needs this panel?
  • Adult Concentration / Focus Issues
  • Headaches / Migraine / Cluster
  • Seizure Disorders
  • Post Concussion Complications
  • Uncontrollable Repetitive Movements / Tics
  • Vertigo / Dizziness
  • Anxiety / Depression / Mood Issues
  • Memory Loss / Mental Deterioration
  • Vision Loss Associated with Retina Damage
  • Neuropathies / Neuralgias

Order Your Personalized Neurological Psych Test Profile which includes:

  • Comprehensive Neurological Psych Test Genetic SNPs.
  • One on one consult with Dr. Hagmeyer to discuss Test Results 
Histamine affects on Brain_DrHagmeyer

Emerging evidence suggests a strong correlation between several single nucleotide polymorphisms (SNPs) and altered brain biology. SNPs change gene codes slightly, which results in a protein that either has improved or reduced functions, or becomes completely inactive.

Therefore, SNPs may play key roles in the development of various pathologies, specifically within the brain tissue, and can greatly affect brain biology and therefore mental health outcomes.

The concentration of the neurotransmitters, the availability of their associated receptors, as well as the enzymes that degrade these neurotransmitters, work together in an orchestrated fashion to closely regulate mood and behaviour which ultimately govern brain and mental health.

Neurotransmitter Receptors

Research has shown that SNPs in the receptors of these neurotransmitters induce alterations in neuronal signaling and have pathophysiological consequences in most cases. Studies have also highlighted the complexity of the various SNPs in the same protein or receptor, leading to largely different mental outcomes. 

The Dopamine Receptor

Several SNPs of the dopamine receptor gene in the striatum of the brain, for example, produce various risk alleles that are associated with increased dopamine signaling and are associated with the development of schizophrenia 2

A different, unrelated SNP in the gene of the dopamine receptor was found to be associated with the pathogenesis of childhood ADHD in male subjects 3

There is also evidence of SNPs in the dopamine gene promoting obesity, metabolic dysfunction, and cognitive change and show that these SNPs are sensitive to obesogenic eating behavior 4,5

The SNPs mentioned above all cause slight changes in the dopamine receptor which dictate the affinity of the receptor to bind efficiently to dopamine. 

This binding then, in combination with external environmental factors, ultimately determines mental health outcomes/pathologies that are experienced by the individual.

Neurotransmitter Degrading Enzymes

As mentioned previously, the uptake and secretion of neurotransmitters are tightly regulated, and if the specific neurotransmitter in question is not readily degraded, or is degraded too slowly after release, neuronal signaling is disrupted. Studies have found that SNPs in genes that code for enzymes that catabolize (break down) neurotransmitters such as dopamine underlie the pathogenesis of a significant number of mental disorders 6,7, but also induce positive changes in pain perception and memory, depending on the SNP 8

Those enzymes responsible for the degradation of serotonin and norepinephrine from neurons are also prone to functional abnormalities due to SNPs, and several studies have demonstrated that SNPs in the gene may confer susceptibility to panic disorder, schizophrenia, depression, and ADHD. Further, low functioning SNPs of the enzyme that degrades serotonin are associated with increased levels of aggression and uniquely correlates with violence.

Neuronal Signaling Molecules 

Biological processes within the brain, such as cell growth, survival, metabolism, memory formation, and synaptic plasticity may also be disrupted by the dysfunction of key signaling molecules associated with these functions. SNPs in the genes encoding these proteins lead to alterations in their intracellular levels, activation and/or inhibition, and their interactions with other molecules. As a result, the SNPs in these susceptible genes have been associated with severe schizophrenia, bipolar disorder, and sporadic Parkinson’s disease.

Neurotransmitters in the brain

Under normal conditions, neurotransmitter release is perfectly timed and ensures that the neurotransmitters access and bind correctly to the neurons in the brain. This is a finely tuned process and therefore if an imbalance in the release or uptake of the neurotransmitters exist, conditions such as depression, anxiety, bipolar disorder, and ADHD may develop1.

The major neurotransmitters in the brain include:

  • Glutamate – the main excitatory neurotransmitter 
  • GABA – the inhibitory neurotransmitter.  

The neuromodulators which play an equally important role in maintaining neuronal function include: 

  • Dopamine
  • Serotonin
  • Norepinephrine
  • Acetylcholine. 

For our Neurological / Psych Nutrigenomic Panel, 27 gene variants have been chosen to be analyzed for SNPs (single nucleotide polymorphisms).

Who needs this panel?

  • Adult Concentration / Focus Issues
  • Headaches / Migraine / Cluster
  • Seizure Disorders
  • Post Concussion Complications
  • Uncontrollable Repetitive Movements / Tics
  • Vertigo / Dizziness
  • Anxiety / Depression / Mood Issues
  • Memory Loss / Mental Deterioration
  • Vision Loss Associated with Retina Damage
  • Neuropathies / Neuralgias

Brain Chemistry of Neurotransmitters

Billions of neurons exist in the brain. These cells share information with other nerve cells through electrical impulses, allowing for thought and communication throughout the body. Neurotransmitters inform many necessary processes like getting your stomach to digest, your heart to beat, or your lungs to breathe. While all neurotransmitters transmit information, they do not all do so in the same manner or with the same intention.
Serotonin & Dopamine – Technically the Only Two Things You Enjoy

There are “inhibitory” neurotransmitters and “excitatory” neurotransmitters. Inhibitory neurotransmitters work to counterbalance excitatory neurotransmitters and are considered the “feel-good” neurotransmitters. GABA, serotonin, and dopamine are among a few. They allow the brain to calm and feel balanced. Excitatory neurotransmitters are responsible for motivation, focus, anxiety, stress, and more. Norepinephrine and epinephrine (noradrenaline and adrenaline) are classified as excitatory, stimulating the brain.

Imbalance of Inhibitory & Excitatory Neurotransmitters

It’s not uncommon for the body to run out of inhibitory neurotransmitters when one has overactive excitatory neurotransmitters. When inhibitory and excitatory neurotransmitters are not working together and are imbalanced, moods like anger, agitation, anxiety, depression can occur.

Change in weight, sleep issues, and poor concentration can also be a byproduct. An estimated 86% of Americans have an imbalance between inhibitory and excitatory neurotransmitters.

Genes Associated With Depression

Depression is not genetically inherited, but the potential for depression in each person is epigenetically modified by environment, stress, genetic makeup and nutritional health.

In the nutrigenomic world, the depression risk factors are associated with two genes that are associated with a higher risk of developing depression. These genes do not guarantee any person will get depression. The specific genes are the MAO and COMT. Both of these genes affect the speed at which neurotransmitters are broken down and cleared from the post synaptic receptor.

In both MAO A and B homozygous and COMT homozygous, the mono-amines are cleared from the receptor site in a sluggish manner. This makes the post synaptic neuron less adaptable to changes in neurotransmitter status and leads to a higher likelihood of depression and/or anxiety in that patient.

By assisting these mutations with methyl donors (ie taurine, methionine, choline, inositol), the practitioner can speed the clearance of the neurotransmitters and lessen the likelihood of developing depression.*

How Neurotransmitter Genetic Testing Can Help

The issues that accompany an imbalance of inhibitory and excitatory neurotransmitters can be exacerbated by specific genetic SNPs in neurotransmitter markers like COMT, MAO-A, MAO-B, GAB 12. Drugs (recreational and/or prescription), neurotoxins, stress, alcohol, poor diet, and caffeine can also fuel symptoms by encouraging these SNPs to further express themselves.

GX Sciences’ neurotransmitter genetic testing shares what SNPs you have within the neurotransmitter markers.

Ultimately, neurotransmitter genetic testing lets doctors and their patients understand their underlying issues with neurotransmitter function and implement personalized solutions.

Neuropsyche Panel Genetic SNPs