Pyrrole disorder is diagnosed with a urine assessment called a kryptopyrrole test. The purpose is to see how many HPL molecules you have in your body. An excessive amount may indicate pyrrole disorder.
Price: $567 (Test+ Consultation)
FAQs
No. This is a cash discount and includes a consultation with Dr Hagmeyer.
This Is a Urine test and can be done from the comfort of your home.
Web results are posted within 7-14 business days. Our office will notify you when test results have been reported.
You will be emailed a confirmation from the lab. Within 3-5 business days, you will receive a test kit that you will take to the lab with you.
Yes. Dr Hagmeyer will review the test result with you. Each test comes with a post-test review/explanation.
One we have placed the order for the test we are unable to issue a refund.
Here are some symptoms that might prompt someone to consider this type of testing:
1. Unexplained Fatigue:
Persistent fatigue or low energy levels may indicate metabolic imbalances or nutrient deficiencies.
2. Frequent Urination:
Increased frequency of urination, especially if accompanied by changes in urine color or odor, may warrant testing to assess kidney function and hydration status.
3. Urinary Tract Symptoms:
Symptoms such as burning during urination, urgency, or pain in the lower abdomen could indicate a urinary tract infection or other issues requiring investigation.
4. Kidney or Bladder Issues:
Individuals with a history of kidney stones, bladder infections, or other urinary tract problems might seek testing to monitor kidney function and metabolic health.
5. Changes in Weight:
Unexplained weight gain or loss may prompt testing to investigate metabolic processes and nutrient absorption.
6. Digestive Issues:
Symptoms like bloating, gas, diarrhea, or constipation could be linked to nutrient malabsorption or metabolic disturbances. Testing for microbial overgrowth is sometimes done through a MOAT Urine test.
7. Nutritional Concerns:
Individuals with dietary restrictions (e.g., vegetarian, vegan) or those who suspect nutrient deficiencies may want to assess their metabolic status through urine testing. In some cases an Organic Acid test test is performed.
8. Hormonal Imbalances:
Symptoms of hormonal issues, such as irregular menstrual cycles, mood swings, or weight changes, may lead to testing to evaluate hormone metabolites. DUTCH testing, 24 hour urine Hormone testing are examples of testing done through urine that provide insight into hormonal imbalances.
9. Skin Issues:
Conditions like acne, eczema, or other skin problems may be linked to metabolic or nutritional imbalances, prompting a urine test.
10. Mood Disorders:
Symptoms of anxiety, depression, or other mental health issues may be associated with metabolic health and nutrient status. Testing of Neurotransmitters is often done through urine.
11. Chronic Inflammation or Pain:
Ongoing inflammation, pain, or autoimmune symptoms might lead to testing to investigate underlying metabolic factors.
12. Post-Surgery or Illness Recovery:
Individuals recovering from surgery or significant illness might undergo urine testing to assess metabolic recovery and overall health status.
If someone is experiencing any of these symptoms, they should consult with a Certified Functional Medicine Practitioner (doctor). The doctor can evaluate the appropriateness of a functional urine test and interpret its results in the context of the person’s overall health and medical history.
Order Your Personalized Kryptopyrrole Test Profile which includes:
- Kryptopyrrole Testing
- One on one consult with Dr. Hagmeyer to discuss Test Results
- Recommendations for a Treatment plan and cost of treatment if necessary.
Pyroluria – A Hidden Cause of Addictions, ADHD, Anxiety and Other Afflictions
Pyrrole disorder or pyroluria is a genetic condition in which an individual produces an abnormally large number of pyrroles. Affected individuals may have 5 – 10 times more pyrroles than are usually produced. Normally excreted in the urine, a pyrrole is a byproduct of hemoglobin synthesis and has no known function in the body.
Hemoglobin, of course, is the molecule that carries oxygen in blood. Pyrroles have an affinity for aldehydes including vitamin B6 and zinc, binding to them in large numbers. They are then excreted in the urine, meaning that the zinc and vitamin B6 nutrients are no longer available for their usual biological roles.
Relapse rates for alcoholism and other addictions are staggering. Likewise, rates of recurrence for common psychiatric disorders – including anxiety, ADHD, and depression – remain high despite aggressive treatments with modern prescription medications. These dire statistics stem from a glaring limitation of contemporary medicine: treatment focuses solely on downstream symptom relief while ignoring upstream root causes of the symptoms in question. One of the more common upstream sources of myriad psychiatric conditions is Pyroluria.
People with pyroluria have been found to have exceptionally low levels of both vitamin B6 and zinc. Deficiencies of these important nutrients have been linked to a wide range of emotional and psychiatric issues including anxiety, irritability, depression, and short-term memory problems.
In addition, pyroluria is often seen in children who have been previously diagnosed with conditions characterized by poor responses to stress, behavioral disorders, learning disorders, ADHD, and autism spectrum disorders. Zinc deficiencies have been associated with physiological disorders as well: poor immune function, poor growth, and delayed puberty.
The Cause Of Pyrrole Disorder
Pyrrole disorder is caused by the overproduction of hydroxyhempyrolin (HPL). The HPL binds zinc and B6 preventing their use by the body and causing excretion in the urine and hair. HPL is a biomarker for oxidative stress and is neurotoxic. Stress of any kind will increases production of pyrroles/HPL which in turn decreases zinc and B6. The reduced utilisation of zinc and B6 is what causes the symptoms of Pyrrole Disorder.
There is evidence to suggest that Pyrrole Disorder is a genetically based ailment as well as a disorder caused by a variety of lifestyle issues such as poor diet, leaky gut syndrome, stress and poor digestion. Statistics and research indicates that if a relative sufferers from Alcoholism, Schizophrenia, Depression, Bipolar Disorder or has suicided, there is a greater risk of Pyrrole Disorder in other family members.
Poor dietary choices and poor digestive health can lead to an increase in Pyrrole levels as a low nutrient diet will not deliver all of the nutrients a body needs much less one with the need for additional support. Leaky Gut Syndrome is common in sufferers of Pyrrole Disorder and a common factor for increasing blood Pyrrole levels. Consider the child with sensory processing, autism spectrum or other oral motor issues, who may have a very select array of foods they are happy to eat. If they are genetically at risk of Pyrrole, plus they eat a strict diet, and possibly have leaky gut, they can manifest the symptoms of Pyrrole disorder (but you’ve got to look at how to manage the underlying triggers of Pyrrole).
Alcohol, smoking, drugs and heavy metal exposure can dramatically increase blood pyrrole levels. This is why people who have Pyrrole Disorder will tend to get a worsening of their symptoms 24 to 48 hours after a big night out drinking or recreational drug use.
Research has discovered that stress increases the production of HPL in your blood, which in turn causes a worsening of your symptoms. It is a well known fact that high levels of cortisol (aka STRESS!) damages the intestinal wall causing intestinal inflammation. Both of which lead to an increase in Leaky Gut Syndrome. Studies have shown that zinc deficiency increases bowel permeability too. Leaky gut is not always from stress and diet, and can actually be due to a candida overgrowth, or other bacterial imbalances in the gut microbiome.
Lifestyle & Supplements Get Results:
With the right diet, supplementation and stress reduction most pyrolurics see results very quickly. More severe cases usually experience slow progressive results. Very stubborn cases are typically having issues with heavy metals or mold toxins.
They will need to remain on this lifestyle with moderate supplementation for the rest of their life or risk symptoms coming back. Typically, large doses of supplementation is used in the beginning and the individual tapers down to smaller doses as they feel better and have a return to nutrient sufficient status.
Vitamin B6 plays a role in cognitive development through the biosynthesis of neurotransmitters and in maintaining normal levels of homocysteine, an amino acid in the blood. It is also involved in glucose metabolism immune function (for example, it promotes lymphocyte and interleukin-2 production), and hemoglobin formation.
Zinc is needed for immune cell function and cell signaling. Zinc decreases oxidative stress and reduces levels of some inflammatory proteins. Chronic oxidative stress will lead to inflammation. And zinc prevents cellular damage in the retina, which helps in delaying the progression of macular degeneration and vision loss. Finally, Zinc also has a crucial role in regulating how neurons communicate with one another, affecting how memories are formed and how we learn.
