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Is Estrogen Causing Your Histamine Intolerance and MCAS Symptoms

Histamine intolerance and hormones like estrogen are interconnected in many ways. Have you ever noticed that your histamine intolerance and MCAS symptoms are worse at certain times of the month especially when you are most prone to estrogen dominance? Hormone imbalances such as low progesterone, low testosterone, Low DHEA, and high estrogen as seen in Estrogen dominance, can significantly impact your histamine levels and promote histamine intolerance/MCAS symptoms.

In today’s video or transcript, depending on where you come across this information, I’m going to explain how your sex hormones including estrogen are connected to histamine intolerance and MCAS, I will talk about the role these hormones play in mast cell instability, how they contribute to the symptoms of histamine intolerance/ MCAS and finally, I will share with you 5 lifestyle tips that will help support histamine levels and hormones.

Is Estrogen Causing Your Histamine Intolerance and MCAS Symptoms

Dealing With Histamine Intolerance/MCAS is Frustrating

Dealing with histamine intolerance/MCAS can be incredibly challenging because many aspects of your health need to be considered- yet they are often overlooked! I talk about Histamine intolerance and MCAS being like a bucket and the more things filling up your bucket- the more you struggle the more you will suffer.

Some people with MCAS and histamine intolerance have a bucket that is filled with all kinds of problems but if you are serious about getting your life back to feeling good again and being in control- Your focus needs to be on understanding what is filling up YOUR bucket- not your FB friends bucket – but your histamine/MCAS bucket! We are all different so what causes your histamine intolerance and MCAS bucket to fill and overflow will be different that mine.

What’s in Your Histamine/MCAS Bucket?

There are several reasons that histamine and other inflammatory mediators can be out of balance. These include things like genetics, the health of your microbiome, childhood environment, stress levels, diet, nutritional deficiencies, liver health, gut health, hormone balance, environmental chemicals, and food.

One by one, these factors fill up your bucket until your bucket begins to overflow. In past videos, I have talked about different problems related to Gut Health, I have talked about the link between Mold biotoxins and Histamine/MCAS and so today, it’s time to focus on the balance of hormones.

For Additional information and Health Tips watch the video below

Estrogen and Sex Hormones- How Estrogen Dominance Affects Mast Cell Stability.

Sex Hormones like estrogen and progesterone affect the mast cells in many ways. While it’s true that more women struggle with histamine intolerance and mast cell activation than men, Estrogen dominance is a known problem in both men and women affected by histamine intolerance.

Studies have shown that Fluctuations of estrogens trigger mast-cell degranulation, while testosterone and other androgens are credited to having a stabilizing effect. Progesterone has also been shown to have a stabilizing effect on mast cells.

Let’s break this up a bit….. what does this mean to you? and how does it apply to your histamine/MCAS symptoms?

The first thing is that this study shows us that estrogen triggers mast cells to break down, when mast cells break down they release histamine as well as other inflammatory chemical immune mediators. We also know from other studies, that high histamine stimulates estrogen- so we have this vicious cycle going on. High estrogen causes mast cells to break apart (degranulate) releasing histamine and we have histamine leading to more estrogen production.

Estrogen Affects DAO Activity

One other thing we know is that Estrogen decreases DAO activity. Estrogen can inhibit the activity of DAO, the enzyme responsible for breaking down histamine in the gut. If you remember from previous videos, DAO is the enzyme that breaks down histamine. If you are a woman who has terrible menstrual cramps, Breast tenderness,  increased heart rate (you feel your heart racing) or you have low blood pressure here is why this is estrogen- histamine connection is important to you.

estrogen histamine intolerance and MCAS

Estrogen Dominance, Histamine Intolerance, and Your Uterus

Estrogen dominance, histamine intolerance, and mast cell activation syndrome (MCAS) are distinct health conditions, but they can be interconnected and share certain overlapping symptoms.

Estrogen dominance occurs when there is an excess of estrogen in relation to progesterone in the body. This hormonal imbalance can be caused by various factors such as hormonal contraceptives, estrogen-like compounds in the environment, stress, and impaired liver function. Symptoms of estrogen dominance may include breast tenderness, irregular menstrual cycles, mood swings, bloating, and weight gain.

Understanding the link between estrogen dominance and histamine intolerance requires a brief anatomy lesson of the uterus. The muscular layer of the uterus is loaded with H1 receptors. When estrogen binds to the H1 receptor you get uterine contractions. Period pain/cramping is often caused by too much estrogen and not enough progesterone.

H1 receptors are not only found in the muscular layer of the uterus, H1 receptors are also found in the heart, the brain, and the inner layer of blood vessels, arteries, and capillaries.

2nd thing that this study points out is that “other” sex hormones like testosterone and other androgens as well as progesterone have a stabilizing effect on mast cells.

So If you are a man and you have low testosterone, or you are a man who has high estrogen you are more prone to suffer with symptoms of histamine intolerance and MCAS symptoms. This might be the man who gets testosterone shots and the testosterone is getting converted into estrogen. So this is one scenario….

2nd scenario applies to a woman who has low progesterone-like that seen in women during menopause and perimenopause, it might be the woman who has high estrogen from synthetic forms of estrogen-like birth control pills, IUD or other forms of hormone therapy, it might be the woman with estrogen dominance or…. It could be the woman with low testosterone.

Estrogen dominance and associated inflammation may also contribute to increased mast cell activation and exacerbation of symptoms.

Synthetic hormones often cause more problems than they fix, they often make histamine and MCAS symptoms worse. So. I recommend that if you are considering using this you research and exhaust all other avenues first.

estrogen histamine intolerance and MCAS

5  Tips to Help Reduce Excess Estrogen and Estrogen Dominance.

Tip #1-Exercise

Exercise is so important- by shedding those extra pounds you will reduce your estrogen load. Estrogen is stored in the fat tissues and the more fat you store the more estrogen-dominant you can become. Fat cells in the breast tissue and belly fat can convert androgens into estrogen. This is called aromatization.

When your testosterone gets converted into estrogen, this leaves you with low testosterone levels. Remember, testosterone and other androgens have a stabilizing effect on the mast cells. The best kind of exercise for promoting healthy testosterone levels is high-intensity interval training.

Tip #2 Change The Kind Of Beauty Products/Personal Health Care Products You Use. 

Most of your personal care products can be major culprits for chemicals that mimic estrogen in your body. These are called xenoestrogens or endocrine disruptors.

Choose natural kinds of makeup, soaps, deodorants, lipsticks, etc also stop using plastic.

Plastic will affect the immune system and cause more hormone imbalances, especially in the thyroid.

Tip #3 Avoid All Forms of Synthetic Hormones When Possible. This Includes Birth Control Pills, Patches, IUDs and HRT.

These hormones wreak havoc on a woman’s hormones because a woman’s body was never designed to be exposed to the synthetic/unnatural and high levels of hormones that you see in HRT, birth control, and patches. These are known to cause very high levels of estrogen and we now know from today’s video, that high levels of Estrogen Cause mast cells to release histamine.

estrogen and histamine intolerance, estrogen and MCAS

If you are a man be very careful with testosterone replacement because for most men with low testosterone- your testosterone is getting converted into estrogen.

Remember testosterone and other androgens, have a stabilizing effect on histamine levels and mast cells. If you take testosterone and your testosterone gets converted into estrogen- you are going to flood your body with more histamine.

Tip #4  Get Your Stress Levels Under Control.

Stress hormones like cortisol have a profound impact on not only your histamine levels but also on Thyroid function, and sex hormones. When someone has been under long-term chronic stress or has experienced thyroid problems, they often experience low cortisol levels. Remember, Cortisol is a hormone produced by the adrenal glands and is responsible for regulating inflammation as well as regulating the stress response.  When cortisol levels are low, inflammation goes unchecked.

Tip #5 Eat more Fiber.

Fiber will keep your bowels regular and help eliminate waste, including unnecessary estrogen.

Final Thoughts about Today’s Video/Article On Estrogen and Histamine Intolerance

  • If you want to feel better and start having more good days than bad days, you need to identify YOUR root causes- what’s filling up YOUR bucket- If you are having symptoms of hormone imbalances or estrogen dominance (PMS, heavy menstrual flow fibrocystic breasts, fibroids, endometriosis, and premenstrual insomnia and anxiety) alongside your histamine intolerance/MCAS symptoms, get your hormones properly evaluated – we can help with this.
  • Estrogen dominance can worsen histamine and MCAS symptoms
  • Testosterone and other androgens as well as progesterone have a stabilizing effect on mast cells.
  • Synthetic hormones often cause more problems than they fix, they often make histamine and MCAS symptoms worse. So. I recommend that if you are considering using this you research and exhaust all other avenues first.
  • Keep this in mind when it comes to testing hormones. There are three main ways to evaluate hormones- Blood, Saliva, and Urine and then there are tests for women who are cycling and women who are not cycling. I recommend starting with these tests.
  • Each of these tests provides information that the other one doesn’t. Which tests YOU need depends on several factors and what’s going on with you. Things like your age, your symptoms, if you are a cycling woman or non-cycling woman, if you are currently on Hormone Replacement therapy, and how long you have been on them. Unfortunately, not knowing anything about you, I don’t know which type of testing is the most appropriate for your needs.
  • When dealing with Histamine intolerance and MCAS, I hope you don’t forget about the important link between Estrogen and histamine intolerance.
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