Histamine intolerance is a distressing condition affecting a growing number of people worldwide. Commonly mistaken for allergies, it manifests through an array of symptoms such as headaches, rashes, digestive issues, and flushing. Managing histamine intolerance requires a multifaceted approach and implementing Natural remedies that have antihistamine effects like Turmeric and Curcumin can be a great supportive therapy.(*) In today’s article, I will explain how Turmeric and Curcumin work as natural anti-histamines for people who have MCAS and histamine intolerance, the powerful benefits of using Curcumin (Turmeric), and why Turmeric from the garden or grocery store falls short of turmeric in supplement form.

Turmeric and Curcumin For Histamine Intolerance and MCAS

Turmeric, a vibrant yellow/orange spice derived from the Curcuma longa plant, has been revered for centuries in traditional medicine, particularly in India and China. In the realm of natural remedies, turmeric (Curcumin) has garnered significant attention for its myriad health benefits, ranging from its anti-inflammatory properties to its immune-modulating effects. Among its diverse therapeutic applications, one of the lesser-known yet precious roles of turmeric is its ability to act as a natural histamine blocker.

What Are Natural Anti-Histamines?

Natural antihistamines like Turmeric/Curcumin can help reduce or counteract the effects of excess histamine in the body in several ways.

1. Block histamine receptors on the cell surface, preventing histamine from binding and thereby reducing allergic symptoms.
2. Turmeric and Curcumin can prevent the release of histamine from mast cells and basophils, the cells that store and release histamine during an allergic response. In this scenario, these natural agents work like natural histamine blockers.(*)
3. Turmeric and Curcumin work by Stabilizing Mast cells- preventing mast cells from breaking open (degranulation) and releasing inflammatory chemicals

Natural histamine blockers like Turmeric also possess anti-inflammatory properties that can reduce overall inflammation in the body, easing the symptoms associated with allergic reactions. Their antioxidant properties also play a role by neutralizing free radicals and reducing oxidative stress linked to inflammation and IgE allergic responses.

For individuals plagued by allergies, histamine intolerance, or conditions like Mast Cell Activation Syndrome (MCAS), exploring the natural antihistamine properties of turmeric (*) could be a game-changer in managing symptoms of Histamine intolerance, MCAS, and allergies. For those who want to know a bit more about the science behind how Turmeric or Curcumin block histamine you can keep reading.

How Turmeric and Curcumin Work as a Natural Histamine Blocker

If you have been struggling with Histamine intolerance or MCAS, you know how important it can be to find natural histamine blockers. The active compound in turmeric, curcumin, is known for its potent anti-inflammatory, antioxidant, antihistamine, and Mast Cell stabilizing properties. (*). This can be incredibly helpful for those patients who don’t respond well to Chromolyn (The drug) that is often prescribed to patients who have MCAS or histamine intolerance. It’s also another option for those patients who are looking for a natural histamine blocker.

1. Anti-Inflammatory Effects: Turmeric and Curcumin’s ability to reduce inflammation is well-documented. In histamine intolerance, where inflammation often plays a significant role, curcumin can help minimize histamine symptoms by lowering inflammatory markers. (*),(*)

2. Antioxidant Properties: Curcumin’s antioxidant properties help in reducing oxidative stress, which is often elevated in allergic responses. By lowering oxidative stress, curcumin can help to alleviate the pro-inflammatory effects of IgE activation. (*)

3. Antihistamine Activity: Research indicates that Turmeric and Curcumin act as a natural antihistamine, blocking the effects of histamines and thereby reducing symptoms such as itching, flushing, and respiratory issues. (*),(*),(*),

4. Gut Health Support: Turmeric promotes digestive health by helping to regulate gut microbiota, improving digestion, and reducing bloating and discomfort often associated with histamine intolerance.(*),(*),(*), (*)

5. Curcumin Inhibits The Activation Of IgE: IgE is a type of antibody associated with allergic reactions. IgE is produced in response to an allergic reaction. Curcumin inhibits IgE activation.(*),(*)

6. Stabilizaation of Mast Cells and Basophils: IgE binds to receptors on mast cells and basophils, leading to their activation and degranulation. Once these cells rupture they release histamine and other mediators of inflammation. Curcumin has been shown to stabilize Mast cells, reducing degranulation and the subsequent release of histamines and other inflammatory mediators. (*),(*). This makes Turmeric and Curcumin a great supportive therapy when you have MCAS.

7. Reduction of Pro-inflammatory Cytokines: Allergic responses and IgE-mediated activation are often accompanied by the release of pro-inflammatory cytokines like IL-4, IL-5, IL-6, and IL-13, IL-18. Turmeric and Curcumin have been shown to reduce the expression and release of these cytokines, contributing to decreased inflammatory responses. (*),(*),(*),(*),(*). This can be very beneficial for patients with MCAS.

8. Inhibits production of Prostaglandins, Thromboxanes, and Leukotrienes- These are chemical mediators that cause Pain, inflammation, smooth muscle contraction, Broncho constriction, and platelets to stick and clump together.(*),(*).

Incorporating Turmeric and Curcumin into Your Diet When You Have Histamine Intolerance

To harness Turmeric’s Histamine blocking benefits, consider these tips for incorporating it into your daily routine: always be aware of any food allergies you may have as this can trigger an immune response leading to more histamine release.

1. Turmeric Tea: Brew a soothing cup of turmeric tea by adding a teaspoon of ground Curcumin (Turmeric) to hot water, along with ginger and honey to taste.

2. Golden Milk: Enjoy a warm, comforting beverage by mixing turmeric with milk (dairy or plant-based), and black pepper.

3. Curries and Soups: Add turmeric to your favorite curry, soup, or stew recipes. It pairs well with other spices such as cumin, coriander, and ginger.

4. Turmeric Supplements: Food is medicine, but Supplementation with Turmeric and Curcumin is superior to dietary incorporation. Keep reading to learn more.

The Best Form Of Turmeric To Take- When You Have Histamine Intolerance or MCAS

One of the primary challenges with Curcumin (Turmeric) is its poor bioavailability, meaning that it is not easily absorbed into the bloodstream when taken orally. This also means that if not taken in the right form, you won’t benefit from the histamine-blocking properties. To enhance its absorption, curcumin is often combined with other substances like piperine (an active component of black pepper), liposomal formulations, or bio-enhanced turmeric extracts.

1. Enhanced Potency: High-quality Curcumin (Turmeric) supplements typically contain extracts standardized to 95% curcuminoids, ensuring you receive a consistent and potent dose of curcumin. For instance, consuming one capsule of turmeric extract is roughly equivalent to consuming several tablespoons of turmeric powder from the root.

2. Improved Absorption: Curcumin is known for its poor bioavailability, meaning it’s not easily absorbed into the bloodstream. Supplements often include components such as piperine (from black pepper) or are formulated with advanced technologies like liposomal to significantly increase curcumin’s absorption.(*) These innovations are crucial, as studies have shown that piperine and liposomal delivery can enhance curcumin absorption by up to 2,000%.

3. Convenience and Consistency: Supplements provide an easy and convenient way to ensure a daily intake of curcumin without the hassle of preparation. Each dose is measured precisely, removing the guesswork often associated with using fresh turmeric in various recipes or teas.

4. Formulation Variety: Turmeric supplements come in various forms, such as capsules, tablets, powders, liquid extracts, and liposomal extracts. The best form of Curcumin (Turmeric) is either in a liposomal formula or in a standardized extract. More on this in just a moment.

Histamine Intolerance or MCAS? Check out this Recipe Section

1. Low Histamine Turmeric & Ginger Roasted Cauliflower
2. Low Histamine Turmeric & Garlic Instant Pot Rice
3. More Low Histamine Recipes 

What You Should Remember About Turmeric and Histamine Intolerance

For those grappling with histamine intolerance or MCAS, Curcumin (Turmeric) offers an appealing natural remedy, thanks to its anti-inflammatory, antioxidant, and antihistamine properties. While dietary adjustments are also necessary for managing histamine intolerance, incorporating turmeric can provide added histamine relief.

While growing turmeric in your garden can be a fun endeavor, (I do it in my own garden) the challenges of achieving consistent potency, proper preparation, and effective dosage make Turmeric and Curcumin supplements a superior and more practical choice for those seeking the therapeutic benefits of curcumin.

The enhanced potency, improved absorption, and convenience of supplements ensure that you receive the maximum health benefits and histamine-blocking benefits this golden spice has to offer.

As you can see with the help of Turmeric and Curcumin as a natural histamine blocker, you can take another proactive step towards alleviating the discomfort of histamine intolerance. As always, consult with a healthcare provider before adding any new supplement to your regimen to ensure it aligns with your health needs and conditions.

Recommended Products

1. CurcuCalm- CurcuCalm works by inhibiting the synthesis of prostaglandins, thromboxanes, and leukotrienes that adversely affect muscle, joint, and connective tissue. This product is great for those with inflammation as CurcuCalm also contains Boswellia (another powerful natural anti-inflammatory). Order CurcuCalm here
2. Liposomal Curcumin– A liposome is a phospholipid (important molecules that provide structure and protection to cells) that forms a barrier around its contents, in this case, the curcuminoids. Liposomes pass through the digestive process without degrading the curcuminoids so that more of it enters the bloodstream and reaches the intended cells and tissues. Order Liposomal Curcumin Here