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We know how frustrating it can be to struggle with Histamine Intolerance and MCAS Symptoms. If you are like most patients you have been on the medical merry go round, bouncing from one doctor to the next. There are many reasons for Histamine Intolerance and MCAS. Let us provide you with the answers you are searching for.

Symptoms Commonly Experienced with Histamine Intolerance/MCAS:

  • Dizziness or vertigo
  • Asthma- Wheezing, labored breathing
  • Irregular or quickened heart rate (arrhythmia)
  • Migraines and/or chronic headaches
  • Light sleeping and difficulty going to sleep
  • Sinus discomfort including congestion, sneezing
  • Cramps
  • Anxiety
  • Fatigue
  • Low Blood Pressure
  • Nausea, vomiting
  • Painful periods (PMS, Menstruation)
  • Hives and/or flushing


 Histamine Intolerance and Mass Cell Activation Syndrome

Histamine Intolerance is NOT a food allergy. Histamine is a chemical that acts as a neurotransmitter, sending information between your body and your brain. It is also a key player in immune system, central nervous system, as well as your digestive tract. Histamine is found in your stomach acid so it has a role in breaking down food as well. While histamine is most commonly thought of in relation to the immune system and seasonal and/or food allergies histamine intolerance is much more.
MCAS and Histamine intolerance symptoms happen when your body can’t break down histamine. Histamine is a chemical signal that opens up your blood vessels, constricts your airways alters gut motility, and alters gut mucus.
Mast cells in your mucous membranes release histamine and other chemical signals to help fight infections and regulate your organs.Your body uses enzymes, mostly diamine oxidase (DAO), to break down histamine.
If you have low levels of DAO and you eat something or take medication that increases your level of histamine, the histamine signals can cause symptoms like diarrhea, headaches, runny nose, itchy skin, red blotches and hives.Histamine intolerance is often accompanied by symptoms such as an itchy tongue and runny nose, while eating certain foods such as banana, avocado, or eggplant. Some patients experience a flushed face when drinking red wine, unpredictable menstrual cycles, or unusual headaches & anxiety. Any of these symptoms could be linked to histamine intolerance. 

Histamine intolerance and Eczema

In addition to the symptoms listed above, excess histamine can make some existing conditions worse. Eczema is an example. Eczema is an inflammatory condition in the skin, sometimes called atopic (allergic) dermatitis. When high histamine foods are consumed, people with less than efficient histamine tolerance may experience an increase in the severity of their eczema.

Histamine and Estrogen Dominance 

The complexity of histamine intolerance extends to the interaction between histamine, estrogen and progesterone in the female body. Mast cells are a key factor underlying these interactions, with the presence of both estrogen and progesterone receptors on mast cells. The binding of estrogen to mast cell receptors stimulates the expression of H2 and H3 receptors, and induces rapid histamine degranulation, synthesis and release. Estrogen can also influence endogenous histamine levels by down regulating DAO activity. This ultimately leads to high histamine levels in the body.

Histamine and The Brain (Anxiety, Migraines, Depression)

Having excess histamine goes way above and beyond your typical allergy symptoms. Excessive histamine can also wreck havoc on the brain. Histamine has been shown to play a pivotal role in many psychiatric disorders such as depression, schizophrenia, anxiety. Because histamine plays a role in wakefulness of the brain, too much histamine can overstimulate the brain leading to anxiety and insomnia as well as restlessness. Any unbalance in the chemical makeup of your brain is bound to cause unwanted effects. These side effects can vary drastically from person to person depending on what Histamine receptor (H1,H2,H3,H4) is stimulated. Brain fog, fatigue, and anxiety are all too common for people who suffer with MCAS and histamine intolerance.

Histamine and Gut Health

SIBO is an intestinal motility disorder that leads to an overgrowth of good or bad bacteria in the small intestine, where few bacteria belong. There are many causes of SIBO however diets high in sugar and refined carbs, antibiotics or other medications that disrupt your delicate microbiome leading to symptoms such as bloating, gas, constipation or diarrehea.

Histamine Stress, Panic attacks and Heart palpitations

Histamine receptors are found all throughout the body and as a result, histamine intolerance affects each of us in different ways. The symptoms that present themselves vary based on which of the four histamine receptors are being activated (H1, 2, 3, 4), and where. In the heart, histamine functions as a vasodilator, meaning that it widens our blood vessels, and therefore there is less resistance to blood pumping through the body this causes a drop in blood pressure.

Whats Filling Up Your Histamine Bucket?

The concept of the “histamine bucket” is a way to visualize this accumulation. It is often depicted as a metaphorical bucket that represents the individual’s capacity to handle and tolerate histamine.

When someone consumes or is exposed to histamine-rich foods, such as fermented products, aged cheeses, or alcohol, or when they experience other triggers like stress, Mold toxins, Genetic Mutations in DAO enzyme, Leaky Gut, Estrogen Dominance, or any of the things you see below, their histamine levels may rise.

As histamine accumulates in the body, it can exceed the individual’s capacity to break it down and eliminate it, causing symptoms of histamine intolerance.

Once the “histamine bucket” overflows, individuals may experience symptoms such as headaches, hives, digestive issues, nasal congestion, itching, flushing, or other allergic-like reactions.

These symptoms can vary in severity and can impact different systems of the body.

histamine intolerance
  • Gut Dysbiosis
  • Small Intestinal Bacterial overgrowth (SIBO)
  • GI bleeding/Inflammation (Ulcers, Crohn’s)
  • Estrogen Dominance, 
  • Low Testosterone
  • Certain Amino Acids ie Histidine
  • Histamine Rich foods such (see list below)
  • Mold Biotoxins (CIRS)
  • High Cortisol Levels 
  • Leaky gut syndrome
  • Food sensitivities
  • Mold Allergies
  • Genetic mutations or SNP’s- can prevent the break down of histamine as well.
histamine intolerance

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  • How to start a Low Histamine Diet
  • Foods to Eat on A Low Histamine Diet
  • Foods To Avoid on Low Histamine Diet
  • Medications that can Cause Histamine Intolerance
  • Common Mistakes made on a Low Histamine diet
  • More..

Is Histamine Intolerance Making You Sick?

For people with histamine intolerance, symptoms tend to increase as the day goes on. Symptoms also worsen if multiple high histamine foods are consumed on the same day or close together. Remember the bucket analogy I mentioned above?. 

Symptoms happen when the bucket fills up due to the combined effect of natural histamine and the histamine consumed in food.

The body’s natural source of histamine can be difficult to control without testing and identifying the cause, but the dietary intake is manageable.

Determining what foods are problematic is an initial step for improving your Histamine intolerance/MCAS. 


For this reason, a histamine intolerance diet and treatment plan looks different for everyone. Luckily, there are some general tips which I have included in this Ebook to get you started. Also, the food lists included in this ebook, is a place to start. They contain foods to avoid or include to decrease the risk of developing symptoms.

Histamine causes a sudden and rapid inflammatory response, setting off an alarm within the immune system that invaders are present. As a result, white blood cells are called upon to swiftly identify and eliminate the foreign bodies. It is the quick flood and build up of histamine that can cause symptoms such as headache, itchiness, flushed face, and overall feeling inflamed and uncomfortable.Histamine works through your bloodstream so high levels that aren’t broken down can potentially harm not only your gut but your lungs, brain, skin, and cardiovascular system. It is for this reason that symptoms can vary from person to person.


Certified in Functional Medicine and Has over 24 Years of Experience

We know that successfully managing Histamine Intolerance and MCAS takes more than just taking antihistamines. That’s why we focus on the whole person and the root causes behind your symptoms. Once you download my free E-book, on the Next page, you will gain access to a several videos that I think you will find incredibly helpful. Treating Histamine intolerance and MCAS is complex. If you are not feeling better, don’t beat yourself up. Successful treatment and management require a whole person approach. Start today by downloading the free histamine E-book and watch the videos on the next page.

Download My eBook Free

Download this E-book today. Then watch the videos on the next page.