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Best Supplements to Help Detox and Cleanse Liver

Are you looking for the best supplements to detox and cleanse your liver? Taking care of your liver is essential for overall health and well-being. As one of the body’s vital organs, the liver plays a critical role in detoxification, metabolism, and nutrient storage. However, factors like poor diet, alcohol consumption, medication use, and environmental toxins can put a strain on the liver, compromising its function that can lead to fatty liver disease. That’s where liver detox and supplements to cleanse liver come into play. In today’s video and article, I will review some of the Best Supplements To Help Detox and Cleanse The Liver. Whether you’re seeking to improve sluggish liver function due to fatty liver disease (NAFLD), boost detoxification pathways, or simply enhance overall liver health, these supplements can provide valuable support.

Symptoms of Sluggish Liver

Are you experiencing symptoms that could indicate a sluggish liver? The liver is responsible for numerous vital functions in the body, including detoxification, metabolism, and nutrient storage. However, various factors such as poor diet, excessive alcohol consumption, medication use, and exposure to environmental toxins can take a toll on this hard-working organ. When the liver becomes overloaded or overwhelmed with toxins, it may not function optimally, resulting in symptoms that can affect your overall health and well-being.

Main Symptoms You Have a Sluggish Liver

  1. Physical Fatigue
  2. Digestive issues (Bloating, Gas, Constipation, Diarrhea)
  3. skin problems
  4. mental Fatigue aka Brain Fog
  5. Mood imbalances

If you’re looking to support your liver’s natural detoxification processes, you may consider supplements to help cleanse and detox your liver. These supplements aim to help eliminate accumulated toxins in the liver, promoting better liver health, better bile flow and function. Whether you’re seeking to boost liver detoxification, enhance liver health, or address specific symptoms related to liver sluggishness, these supplements can be beneficial. Join us as we dive deeper into the symptoms of a sluggish liver and explore the power of liver detoxification, liver flushes, and the best supplements for liver detox.

Best Supplements to Detox and Cleanse Liver

I’m often asked about the best supplements to help Detox and cleanse liver when it’s sluggish or when you are diagnosed with Fatty Liver Disease (NAFLD). So, in today’s video, I’m going to go through some of the most crucial ingredients you want to see if you are going to do a liver cleanse or liver detox.

In my last video, I talked about some of the Best Foods To Eat To Support, Heal, Cleanse and Detox Your Liver, but to be honest most of us have had years and years of toxin exposure (if we are being honest) and so…… in many cases, while eating these foods daily is a must, for most of us, food just isn’t enough.

In most cases your liver needs additional support to reduce its toxic load/burden and this is more easily achieved with supplementation and detox programs. With that said, there are lots of Detox program and liver cleanses on the market and one of the reason I wanted to shoot this video is to help my patients and perhaps even my subscribers on my YouTube channel have a better understanding of WHAT these different herbs and nutrients do and WHY they are important and WHY I recommend them.

Consider this….

Chronic liver diseases, including fatty liver diseases, hepatitis, fibrosis, cirrhosis, and cancer, are major global health problems [*] and if your doctor told you that you have elevated liver enzymes the information in this video and the video I did on How To Safely Detox your Liver with food” is something you want to watch and maybe even discuss with your doctor. When it comes to liver problems, there are 5 main considerations and this is super important if you have elevated liver enzymes, or elevated CRP levels or any blood marker related to liver function. So outside of having bloodwork where your liver enzymes may be elevated, and you have high triglycerides, high cholesterol, why would someone want to take supplement for their liver or do a liver detox or liver cleanse anyway?

how supplements benefit the liver

 7 Reasons Supplements Benefit Your Liver

There are many reasons to take supplements to Cleanse and Detox the Liver, but let’s consider these seven reasons.

  1. When your liver is sluggish, every organ in your body is affected. It’s not uncommon to see Fatty Liver disease with a sluggish liver.  A toxic liver may struggle to make bile. Bile is needed to absorb fats but also to eliminate toxins from the body.
  2. If you have hormone imbalances, A sluggish liver will struggle with eliminating excess estrogen, hormone metabolism in the body, so symptoms of estrogen dominance can develop.
  3. A sluggish liver can very often lead to blood sugar fluctuations which in turn can lead to insulin resistance, hypoglycemia,
  4. A sluggish liver can very often lead to Small Intestinal Bacterial Overgrowth(SIBO), Candida overgrowth and gut dysbiosis
  5. A sluggish liver leads to a fatty liver disease this could lead to more serious problems if fat continues to collect in your liver.
  6. A sluggish liver can affect thyroid hormone levels causing problems with thyroid function. Your liver is the major site for the conversion of T4 into T3
  7. A liver overloaded with pollutants and toxins cannot efficiently burn body fat, and thus will sabotage your weight loss efforts.

So now that you know why it’s important to take care of your liver, now let’s get into some of the best supplements for supporting, improving, and maintaining the health of your liver.

Best Supplements for Improving and Supporting Liver Health

selenium and liver detoxification


Selenium is a vital mineral that plays a crucial role in supporting liver health and function. When it comes to liver detoxification and liver cleansing and the best liver supplements, selenium is one of my top 7 best supplements. Selenium is known for its ability to support the liver’s natural detoxification processes.

One of the liver’s primary functions is to detoxify harmful substances, such as toxins, heavy metals, and medications. This process involves various enzymatic reactions that convert these substances into water-soluble forms, allowing them to be safely eliminated from the body. Selenium acts as a cofactor for a group of enzymes called glutathione peroxidases, which are responsible for neutralizing harmful free radicals and protecting liver cells from oxidative damage.

Glutathione, often referred to as the “master antioxidant,” is vital for proper detoxification. Heres why selenium is so important when it comes to glutathione. Selenium supports glutathione production in the liver, enhancing its antioxidant activity and aiding in the removal of toxins. By increasing glutathione levels, selenium helps to protect liver cells from damage, reduce inflammation, and support optimal liver function.

Furthermore, selenium has been found to have a protective effect against liver injury caused by toxic substances. It helps to prevent lipid peroxidation (*), a process in which free radicals damage cell membranes, leading to liver cell death. By inhibiting lipid peroxidation, selenium helps to preserve the structural integrity and overall health of liver cells.

In addition to its direct impact on liver detoxification, selenium also plays a role in immune function. A healthy immune system is crucial for liver health, as it helps fight off infections and aids in the repair and regeneration of liver cells. Selenium’s ability to support immune function can indirectly support the liver’s detoxification capacity.

The liver uses selenium to make glutathione peroxidase, this is one of several glutathione-based compounds needed for liver detoxification. Many diseases of the liver can lead to rigidity in the tissues and local blood vessels. Selenium helps to preserve and retain elasticity while also supporting healthy hepatic circulation. Because oxidation is linked to liver damage, antioxidants such as selenium are vital for preserving liver tissue(*).

alpha lipoic acid and how it supports liver cleanse

2.Alpha-Lipoic Acid

Alpha-lipoic acid has been used to treat patients with liver cirrhosis, liver failure, mushroom poisoning, high fat diet induced fatty liver, hepatitis, LPS induced live injury even liver cirrhosis. (*) Alpha-lipoic acid (ALA) is a powerful antioxidant that has been shown to have several beneficial effects on liver health. When it comes to detoxification and liver cleansing, ALA offers unique properties that support optimal liver function.

One of the primary ways that ALA helps with liver detoxification is by promoting the production of glutathione. Glutathione is a critical antioxidant and detoxifier that is naturally produced by the liver. It plays a key role in neutralizing and removing toxins from the body. ALA enhances glutathione levels by both increasing its synthesis and recycling it after it has been used. This increase in glutathione levels enhances the liver’s ability to neutralize and eliminate harmful substances.

In addition to its effects on glutathione, ALA has also been shown to have direct antioxidant properties. It can neutralize free radicals, which are unstable molecules that can damage cells and tissues. By reducing oxidative stress in the liver, ALA helps protect liver cells from damage and supports the overall health of the liver.

Furthermore, ALA has been found to have anti-inflammatory effects. Inflammation is a common feature of liver diseases and can impair liver function. ALA helps to reduce inflammation in the liver, which not only supports the detoxification process but also aids in the regeneration and repair of liver tissues.

Studies have also shown that ALA has hepatoprotective properties, meaning it can help protect the liver from injury and damage. It has been shown to protect against toxic substances, such as heavy metals and chemicals, which can accumulate in the liver and impair its function. Alpha-lipoic Acid also helps with insulin resistance and blood sugar problems which are leading root causes of a fatty liver disease. (*)

NAC and liver cleanse fatty liver disease

3. N-Acetylcysteine (NAC)

Many people who struggle with common chronic illnesses have depleted glutathione levels, including those with chronic fatigue syndrome, Diabetes, Metabolic Syndrome, heart disease, cancer, chronic infections, autoimmune disease, diabetes, Alzheimer’s disease, Parkinson’s disease, kidney problems and liver disease (*). Your body’s ability to produce and maintain adequate glutathione levels is vital to recovery from illness, disease prevention and maintaining optimal health. N-Acetyl cysteine is so important because is a precursor to the powerful antioxidant glutathione, which helps neutralize cell-damaging free radicals that cause inflammation and fatty buildup in the liver. Non-alcoholic fatty liver (NAFLD) is a common disease of the liver in which oxidative stress plays a role. (*) Glutathione protects the liver.

NAC has several mechanisms through which it supports liver detoxification: Heres what you should remember about NAC.

1. Glutathione Booster: NAC provides cysteine, an amino acid necessary for the synthesis of glutathione. By supplying this precursor, NAC supports the liver in producing adequate amounts of glutathione. Glutathione plays a vital role in detoxification by binding to toxins, heavy metals, and free radicals, neutralizing them, and facilitating their elimination from the body.

2. Increased Glutathione Availability: NAC not only supports glutathione synthesis but also helps replenish and regenerate existing glutathione stores in the liver. This is particularly important in situations where liver detoxification pathways are overwhelmed or depleted. By enhancing glutathione availability, NAC assists in the efficient removal of toxins and harmful substances from the liver.

3. Antioxidant Activity: NAC itself has antioxidant properties. It acts as a scavenger of free radicals and reactive oxygen species (ROS) that can cause oxidative stress and damage to liver cells. By reducing oxidative stress, NAC helps protect the liver from inflammation and cell death, promoting overall liver health and optimal detoxification function.

4. Liver Detoxification Enzyme Support: NAC has been found to support the activity of certain liver enzymes involved in detoxification processes. These enzymes, such as glutathione peroxidase and glutathione-S-transferase, are responsible for converting toxins into less harmful or more easily eliminated forms. By enhancing the activity of these enzymes, NAC aids in the efficient detoxification of harmful substances in the liver.

5. Mucolytic Properties: Apart from its role in liver detoxification, NAC is also known for its mucolytic properties. It helps break down and thin mucus, making it easier to clear from the respiratory tract. This function is important as the liver detoxification process involves the excretion of waste products and toxins through bile, which is then eliminated via the digestive tract. By supporting the health of the respiratory and digestive systems, NAC indirectly promotes efficient detoxification.

Milk thistle and liver detoxification

4. Milk Thistle aka Silymarin

Milk thistle also known as Silmarin, is one the most popular liver supplements for treating and repairing damage to liver cells caused by disease, alcohol, medications. (*) where do we start with Milk thistle?  Milk thistle (Silybum marianum) is a herb that has been used for centuries to support liver health and detoxification. The active compound in milk thistle is silymarin, which is a mixture of flavonolignans including silybin, silydianin, and silychristin. Here’s how milk thistle helps with liver detoxification:

1. Antioxidant Activity: Silymarin in milk thistle has potent antioxidant properties. It helps neutralize free radicals and reduces oxidative stress in the liver. Oxidative stress can damage liver cells and impair detoxification processes.(*)

2. Liver Cell Protection: Milk thistle can help protect liver cells through its anti-inflammatory and anti-fibrotic effects. It inhibits the production of inflammatory chemicals and enzymes, reducing inflammation in the liver. By preventing inflammation and fibrosis, milk thistle supports healthy liver tissue and optimal detoxification function. (*).

3. Enhanced Detoxification Enzyme Activity: Milk thistle has been shown to increase the activity of certain liver enzymes involved in detoxification, such as glutathione S-transferase and superoxide dismutase. These enzymes play a crucial role in breaking down and eliminating toxins from the body. By enhancing their activity, milk thistle helps boost the liver’s detoxification capabilities.

4. Support for Liver Regeneration: Milk thistle has been shown to stimulate the production of new liver cells and promote liver tissue regeneration. This can be particularly beneficial in cases of liver damage or injury caused by toxins or certain medications. By supporting liver regeneration, milk thistle aids in the recovery and restoration of liver function. (*)

5. Bile Flow Enhancement: Milk thistle can help increase the flow of bile from the liver. Bile is essential for the excretion of toxic substances, cholesterol, and other waste products. By enhancing bile production and flow, milk thistle promotes the elimination of toxins and waste from the liver and the body. (*)

Glutathione and liver cleanse liver detoxification


Glutathione is known as the body’s master antioxidant, it’s critical for protecting cells from oxidative stress and the damage caused from toxins. Unfortunately, glutathione levels decline significantly with age and with illness.

By age 65, there is a 50% reduction in our active glutathione levels. Stressors like disease and environmental factors tax glutathione levels as well. The greater the stressors, the greater the need for glutathione. Without antioxidants like glutathione, unstable free radicals (due to unstable molecular composition) could initiate chain reactions that damage cells and their cellular DNA.

This oxidative stress can cause excessive inflammation, may kill cells, affect cellular replication and regeneration, and if the situation becomes chronic, may play a significant role in many human diseases.

Glutathione could be called a Super antioxidant. Not only does it work as an antioxidant, but it also boosts the power of other antioxidants in our bodies, like vitamins C and E.

In other words, glutathione regenerates or recycles these vitamins after they have been used up or “spent.” Glutathione helps remove heavy metals such as mercury, aluminum, and cadmium from your body, and it also helps eliminate toxins found in plastics and conventional cosmetic products or in mold. Our body’s glutathione production can be halted by intense physical activity over extended periods, which is why so many athletes use Glutathione.

6.Amino Acids and BCAA

Amino acids like methionine, cysteine, glutamine, choline, taurine, histidine, serine, glycine and branched chain amino acids are needed for various aspects of liver health and detoxification. Here are some ways in which amino acids support liver detoxification:

1. Glutathione Synthesis: Amino acids such as cysteine, glycine, and glutamine are essential for the synthesis of glutathione, a powerful antioxidant and detoxifying agent produced in the liver. Glutathione plays a crucial role in neutralizing toxins, heavy metals, and free radicals, making them less harmful and facilitating their elimination from the body.

2. Methylation Pathways: Certain amino acids are involved in methylation processes, which are essential for detoxification in the liver. Methylation reactions help convert toxins into less harmful and more easily eliminated forms. Amino acids like methionine, glycine, and serine are necessary for these reactions, supporting the efficient removal of toxins from the body.

3. Phase II Detoxification Enzymes: Amino acids are crucial for the synthesis and activation of several phase II detoxification enzymes in the liver. These enzymes, such as glutathione-S-transferase, N-acetyltransferases, and sulfate transferase, help bind toxins and convert them into water-soluble forms. Amino acids provide the building blocks necessary for the production and proper functioning of these enzymes, supporting effective detoxification. In phase II detoxification, liver cells add different kinds of amino acids to a toxic chemical or drug, to make it less harmful. This is why amino acids are so important for detoxification. Studies done with humans have confirmed that amino acid supplements can naturally and effectively treat both nonalcoholic fatty liver disease and alcoholic liver disease, the top two causes of liver disease-related deaths.

Several clinical trials found that essential amino acids reduce liver fat as effectively as fenofibrate, a top pharmacological treatment for high cholesterol, high triglycerides and low good cholesterol. The upside to amino acids is that they don’t come with a long list of side effects the way many of the fibrate medications do. Fever, hives and other skin rashes, muscle aches and pains, stomach pain, constipation, joint pain, headaches, and vomiting are all side effects of fibrate medications.

4. Protein Synthesis: Amino acids are the building blocks of proteins, which play a crucial role in liver detoxification. Proteins, such as cytochrome P450 enzymes, are responsible for metabolizing and detoxifying a wide range of exogenous and endogenous compounds. Adequate intake of amino acids ensures that the liver has the necessary raw materials to produce these detoxification proteins.

Let’s talk about choline for liver health.

    Choline and liver health

7. Choline

Nine in 10 Americans are not consuming enough choline to ensure optimal health, according to a study published in the Journal of the American College of Nutrition. Your brain and nervous system need choline to regulate memory, mood, muscle control, and other functions. Choline is a compound that makes up the structural component of fat. Choline is particularly important for liver health, as it is required for the proper transportation of fat (cholesterol and Triglycerides) from the liver to cells throughout the body.

Choline is an essential nutrient that plays a crucial role in liver health and function especially when it comes to toxins. Toxins are fat soluble meaning that they dissolve in fat. Choline helps the liver because it prevents the accumulation of fat in the liver. Excess fat in the liver leads to non-alcoholic fatty liver disease (*) like I have been talking about but also a buildup of toxins.- Remember Toxins are lipophilic meaning they get stored in fat. Choline helps remove that fat build up. Because Choline it is required for healthy muscle and nerve functioning, it may also be helpful in preventing fatigue and muscle aches or pains following exercise. If we sum up the benefits of choline, they can be as followed.

1.Fat Metabolism: Choline is essential for the metabolism of fats in the liver(*). It helps transport fats and cholesterol from the liver to other parts of the body, preventing the accumulation of fat in the liver and promoting healthy liver function. Choline is a component of phosphatidylcholine, a major component of cell membranes and lipoproteins responsible for transporting fats.

2. Liver Protection: Choline acts as a hepatoprotective agent, helping to protect liver cells from damage(*). It enhances the integrity of liver cell membranes and supports their optimal function. By preserving liver cell structure and function, choline helps maintain liver health and overall liver detoxification processes.

3. Phospholipid Synthesis: Choline is necessary for the synthesis of phospholipids, including phosphatidylcholine, which is a major component of liver cell membranes. Phospholipids play a crucial role in maintaining the fluidity and integrity of cell membranes, ensuring efficient transport of nutrients and elimination of waste products. Adequate choline intake supports the synthesis of phospholipids, facilitating normal liver cell function and detoxification processes.

4. Methylation Reactions: Choline is involved in methylation reactions in the liver, contributing to detoxification processes(*). Methylation reactions help convert toxins and harmful substances into less toxic and more easily eliminated forms. Choline, along with other methyl donors like folate, vitamins B6 and B12, supports these methylation reactions, promoting efficient liver detoxification.

5. Prevention of Liver Diseases: Choline deficiency has been associated with the development of liver diseases such as non-alcoholic fatty liver disease (NAFLD) and liver fibrosis(*). Adequate choline intake helps prevent the accumulation of fat in the liver and the development of these conditions. Supplementing with choline may be beneficial for individuals with choline deficiency or liver health concerns.

What You Should Remember About This Article

As one of the body’s vital organs, the liver plays a critical role in detoxification, metabolism, and nutrient storage. Factors like poor diet, alcohol consumption, medication use, and environmental toxins can put a strain on the liver, compromising its function that can lead to fatty liver disease. That’s where liver detox and supplements to cleanse liver come into play. Today we touched on Choline, Glutathione, NAC, Alpha Lipoic Acid, Selenium, milk thistle aka silymarin and amino acids.

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